Neuroinflammation in Parkinson’s disease and its potential as therapeutic target
Chinese Academy of Sciences · Center for Excellence in Brain Science and Intelligence Technology · +1 more institution
Abstract
Parkinson's disease (PD), the second most common age-associated neurodegenerative disorder, is characterized by the loss of dopaminergic (DA) neurons and the presence of α-synuclein-containing aggregates in the substantia nigra pars compacta (SNpc). Chronic neuroinflammation is one of the hallmarks of PD pathophysiology. Post-mortem analyses of human PD patients and experimental animal studies indicate that activation of glial cells and increases in pro-inflammatory factor levels are common features of the PD brain. Chronic release of pro-inflammatory cytokines by activated astrocytes and microglia leads to the exacerbation of DA neuron degeneration in the SNpc. Besides, peripheral immune system is also…
Citation impact
- FWCI
- 33.73
- Percentile
- 100%
- References
- 125
Authors
3- QWQinqin WangCorresponding
- YLYingjun Liu
Chinese Academy of Sciences, Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences
- JZJiawei Zhou
Shanghai Institutes for Biological Sciences, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences
Topics & keywords
- Neuroinflammation
- Neurology
- Parkinson's disease
- Disease
- Medicine
- Neuroscience
- Deep brain stimulation
- Psychology
- Good health and well-being