articleBrainMar 31, 2009BRONZE OA

Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease

CRClifford R. JackVJVal J. LoweSDStephen D. WeigandHJHeather J. WisteMLMatthew L. Senjem

Mayo Clinic · San Francisco VA Medical Center · +1 more institution

PubMed
Indexed incrossrefpubmed

Abstract

The purpose of this study was to use serial imaging to gain insight into the sequence of pathologic events in Alzheimer's disease, and the clinical features associated with this sequence. We measured change in amyloid deposition over time using serial (11)C Pittsburgh compound B (PIB) positron emission tomography and progression of neurodegeneration using serial structural magnetic resonance imaging. We studied 21 healthy cognitively normal subjects, 32 with amnestic mild cognitive impairment and 8 with Alzheimer's disease. Subjects were drawn from two sources--ongoing longitudinal registries at Mayo Clinic, and the Alzheimer's disease Neuroimaging Initiative (ADNI). All subjects underwent clinical…

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1,084
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100%
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Authors

12

Topics & keywords

Topics
Keywords
  • Pittsburgh compound B
  • Atrophy
  • Magnetic resonance imaging
  • Alzheimer's disease
  • Cardiology
  • Dementia
  • Psychology
  • Positron emission tomography
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