Intestinal permeability – a new target for disease prevention and therapy
University of Hohenheim · University of Bologna · +9 more institutions
Abstract
Data are accumulating that emphasize the important role of the intestinal barrier and intestinal permeability for health and disease. However, these terms are poorly defined, their assessment is a matter of debate, and their clinical significance is not clearly established. In the present review, current knowledge on mucosal barrier and its role in disease prevention and therapy is summarized. First, the relevant terms 'intestinal barrier' and 'intestinal permeability' are defined. Secondly, the key element of the intestinal barrier affecting permeability are described. This barrier represents a huge mucosal surface, where billions of bacteria face the largest immune system of our body. On the one hand, an…
Citation impact
- FWCI
- 32.15
- Percentile
- 100%
- References
- 272
Authors
9Topics & keywords
- Medicine
- Hepatology
- Intestinal permeability
- Internal medicine
- Disease
- Intensive care medicine
- Gastroenterology