Atherosclerotic Plaque Progression and Vulnerability to Rupture
University of Maryland, Baltimore · Thomas Jefferson University · +4 more institutions
Abstract
Observational studies of necrotic core progression identify intraplaque hemorrhage as a critical factor in atherosclerotic plaque growth and destabilization. The rapid accumulation of erythrocyte membranes causes an abrupt change in plaque substrate characterized by increased free cholesterol within the lipid core and excessive macrophage infiltration. Neoangiogenesis is associated closely with plaque progression, and microvascular incompetence is a likely source of intraplaque hemorrhage. Intimal neovascularization is predominantly thought to arise from the adventitia, where there are a plethora of pre-existing vasa vasorum. In lesions that have early necrotic cores, the majority of vessels invading from the…
Citation impact
- FWCI
- 18.33
- Percentile
- 100%
- References
- 73
Authors
8- RVRenu VirmaniCorresponding
University of Maryland, Baltimore, Thomas Jefferson University, University of California, Irvine, Thomas Jefferson University Hospital, CVPath Institute, Drexel University
- FDFrank D. Kolodgie
University of Maryland, Baltimore, Thomas Jefferson University, University of California, Irvine, Thomas Jefferson University Hospital, CVPath Institute, Drexel University
- ABAllen Burke
University of Maryland, Baltimore, Thomas Jefferson University, University of California, Irvine, Thomas Jefferson University Hospital, CVPath Institute, Drexel University
- AVAloke V. Finn
University of Maryland, Baltimore, Thomas Jefferson University, University of California, Irvine, Thomas Jefferson University Hospital, CVPath Institute, Drexel University
- HKHerman K. Gold
University of Maryland, Baltimore, Thomas Jefferson University, University of California, Irvine, Thomas Jefferson University Hospital, CVPath Institute, Drexel University
Topics & keywords
- Vasa vasorum
- Adventitia
- Medicine
- Pathology
- Lesion
- Lumen (anatomy)
- Neovascularization
- Fibrous cap