articleScienceSep 3, 2015Closed access

Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells

MJMartijn J. SchuijsMWMonique WillartKVKarl VergoteDGDelphine GrasKDKim Deswarte

Ghent University · VIB-UGent Center for Inflammation Research · +6 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Growing up on a dairy farm protects children from allergy, hay fever, and asthma. A mechanism linking exposure to this endotoxin (bacterial lipopolysaccharide)-rich environment with protection has remained elusive. Here we show that chronic exposure to low-dose endotoxin or farm dust protects mice from developing house dust mite (HDM)-induced asthma. Endotoxin reduced epithelial cell cytokines that activate dendritic cells (DCs), thus suppressing type 2 immunity to HDMs. Loss of the ubiquitin-modifying enzyme A20 in lung epithelium abolished the protective effect. A single-nucleotide polymorphism in the gene encoding A20 was associated with allergy and asthma risk in children growing up on farms. Thus, the…

Citation impact

571
total citations
FWCI
29.72
Percentile
100%
References
33
Citations per year

Authors

14

Topics & keywords

Topics
Keywords
  • Allergy
  • Immunology
  • House dust mite
  • Lipopolysaccharide
  • Asthma
  • Hay fever
  • Biology
  • Allergen
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