Recurring Mutations Found by Sequencing an Acute Myeloid Leukemia Genome
Washington University in St. Louis · New York Genome Center · +3 more institutions
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Abstract
Background
The full complement of DNA mutations that are responsible for the pathogenesis of acute myeloid leukemia (AML) is not yet known.
Methods
We used massively parallel DNA sequencing to obtain a very high level of coverage (approximately 98%) of a primary, cytogenetically normal, de novo genome for AML with minimal maturation (AML-M1) and a matched normal skin genome.
Citation impact
2,225
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- FWCI
- 117.17
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- References
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Authors
58Topics & keywords
Topics
Keywords
- Genome
- Biology
- Genetics
- Neuroblastoma RAS viral oncogene homolog
- Gene
- Mutation
- Point mutation
- Myeloid leukemia
UN Sustainable Development Goals
- Life in Land
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