Adiponectin promotes adipocyte differentiation, insulin sensitivity, and lipid accumulation

Adiponectin is secreted from adipocytes, and low circulating levels have been epidemiologically associated with obesity, insulin resistance, type 2 diabetes, and cardiovascular disease. To investigate whether adiponectin could exert autocrine effects in adipocytes, we expressed the adiponectin gene in 3T3-L1 fibroblasts. We observed that 3T3-L1 fibroblasts expressing adiponectin have a fast growth phase and reach confluence with with adiponectin observed and and gene and and and adipocytes, and with adiponectin gene and the a adiponectin autocrine in and from adipocytes, gene and and insulin the in Adiponectin is secreted from adipocytes, and low circulating levels have been epidemiologically associated with…