The Prioritization of Cancer Antigens: A National Cancer Institute Pilot Project for the Acceleration of Translational Research
Memorial Sloan Kettering Cancer Center · University of Pittsburgh · +4 more institutions
Abstract
The purpose of the National Cancer Institute pilot project to prioritize cancer antigens was to develop a well-vetted, priority-ranked list of cancer vaccine target antigens based on predefined and preweighted objective criteria. An additional aim was for the National Cancer Institute to test a new approach for prioritizing translational research opportunities based on an analytic hierarchy process for dealing with complex decisions. Antigen prioritization involved developing a list of "ideal" cancer antigen criteria/characteristics, assigning relative weights to those criteria using pairwise comparisons, selecting 75 representative antigens for comparison and ranking, assembling information on the predefined…
Citation impact
- FWCI
- 22.37
- Percentile
- 100%
- References
- 90
Authors
11- MAMartin A. CheeverCorresponding
Memorial Sloan Kettering Cancer Center, University of Pittsburgh, Georgetown University, Fred Hutch Cancer Center, National Cancer Institute, Georgetown Lombardi Comprehensive Cancer Center
- JPJames P. Allison
Memorial Sloan Kettering Cancer Center, University of Pittsburgh, Georgetown University, Fred Hutch Cancer Center, National Cancer Institute, Georgetown Lombardi Comprehensive Cancer Center
- ASAndrea Stern Ferris
Memorial Sloan Kettering Cancer Center, University of Pittsburgh, Georgetown University, Fred Hutch Cancer Center, National Cancer Institute, Georgetown Lombardi Comprehensive Cancer Center
- OJOlivera J. Finn
Memorial Sloan Kettering Cancer Center, University of Pittsburgh, Georgetown University, Fred Hutch Cancer Center, National Cancer Institute, Georgetown Lombardi Comprehensive Cancer Center
- BMBenjamin M. Hastings
Memorial Sloan Kettering Cancer Center, University of Pittsburgh, Georgetown University, Fred Hutch Cancer Center, National Cancer Institute, Georgetown Lombardi Comprehensive Cancer Center
Topics & keywords
- Antigen
- Cancer
- Pairwise comparison
- Cancer vaccine
- Ranking (information retrieval)
- Immunogenicity
- Computational biology
- Medicine