Statin-associated muscle symptoms: impact on statin therapy—European Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and Management

Stroes, Erik S.G.; Thompson, Paul D.; Corsini, Alberto; Vladutiu, Georgirene D.; Raal, Frederick J.; Ray, Kausik K.; Roden, Michael; Stein, Evan A.; Tokgözoğlu, Lâle; Nordestgaard, Børge G.; Bruckert, Éric; Backer, Guy De; Krauss, Ronald M.; Laufs, Ulrich; Santos, Raúl D.; Hegele, Robert A.; Hovingh, G. Kees; Leiter, Lawrence A.; Mach, François; März, Winfried; Newman, Connie B.; Wiklund, Olov; Jacobson, Terry A.; Catapano, Alberico L.; Chapman, M. John; Ginsberg, Henry N.; Panel, European Atherosclerosis Society Consensus; Stroes, Erik S.G.; Thompson, Paul D.; Corsini, Alberto; Vladutiu, Georgirene D.; Raal, Frederick J.; Ray, Kausik K.; Roden, Michael; Stein, Evan A.; Tokgözoğlu, Lâle; Nordestgaard, Børge G.; Bruckert, Eric; Krauss, Ronald M.; Laufs, Ulrich; Santos, Raul D.; März, Winfried; Newman, Connie B.; Chapman, M. John; Ginsberg, Henry N.; Chapman, M. John; Ginsberg, Henry N.; Backer, Guy De; Catapano, Alberico L.; Hegele, Robert A.; Hovingh, G. Kees; Jacobson, Terry A.; Leiter, Lawrence A.; Mach, François; Wiklund, Olov

doi:10.1093/eurheartj/ehv043

reviewEuropean Heart JournalFeb 18, 2015HYBRID OA

Statin-associated muscle symptoms: impact on statin therapy—European Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and Management

ESErik S.G. StroesPDPaul D. ThompsonACAlberto Corsini GDGeorgirene D. Vladutiu FJFrederick J. Raal

Amsterdam UMC Location University of Amsterdam · Hartford Hospital · +29 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Statin-associated muscle symptoms (SAMS) are one of the principal reasons for statin non-adherence and/or discontinuation, contributing to adverse cardiovascular outcomes. This European Atherosclerosis Society (EAS) Consensus Panel overviews current understanding of the pathophysiology of statin-associated myopathy, and provides guidance for diagnosis and management of SAMS. Statin-associated myopathy, with significant elevation of serum creatine kinase (CK), is a rare but serious side effect of statins, affecting 1 per 1000 to 1 per 10 000 people on standard statin doses. Statin-associated muscle symptoms cover a broader range of clinical presentations, usually with normal or minimally elevated CK levels,…

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Topics & keywords

Topics

Keywords

Medicine
Statin
myalgia
Discontinuation
Myopathy
Internal medicine
Atorvastatin
Physical therapy

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