Treatment of Acute Venous Thromboembolism With Dabigatran or Warfarin and Pooled Analysis
Thrombosis Research Institute · University College London · +1 more institution
Abstract
BACKGROUND: Dabigatran and warfarin have been compared for the treatment of acute venous thromboembolism (VTE) in a previous trial. We undertook this study to extend those findings. METHODS AND RESULTS: In a randomized, double-blind, double-dummy trial of 2589 patients with acute VTE treated with low-molecular-weight or unfractionated heparin for 5 to 11 days, we compared dabigatran 150 mg twice daily with warfarin. The primary outcome, recurrent symptomatic, objectively confirmed VTE and related deaths during 6 months of treatment occurred in 30 of the 1279 dabigatran patients (2.3%) compared with 28 of the 1289 warfarin patients (2.2%; hazard ratio, 1.08; 95% confidence interval [CI], 0.64-1.80; absolute…
Citation impact
- FWCI
- 86.99
- Percentile
- 100%
- References
- 27
Authors
11- SSSam SchulmanCorresponding
Thrombosis Research Institute, University College London
- AKAjay K. Kakkar
Thrombosis Research Institute, University College London
- SZSamuel Z. Goldhaber
Thrombosis Research Institute, University College London
- SSSebastian Schellong
Thrombosis Research Institute, University College London
- HEHenry Eriksson
Thrombosis Research Institute, University College London
Topics & keywords
- Medicine
- Dabigatran
- Warfarin
- Hazard ratio
- Confidence interval
- Internal medicine
- Surgery
- Anesthesia
- Good health and well-being