Angiogenic Factors and the Risk of Adverse Outcomes in Women With Suspected Preeclampsia
National Institutes of Health · Beth Israel Deaconess Medical Center · +4 more institutions
Abstract
BACKGROUND: An imbalance in circulating angiogenic factors plays a central role in the pathogenesis of preeclampsia. METHODS AND RESULTS: We prospectively studied 616 women who were evaluated for suspected preeclampsia. We measured plasma levels of antiangiogenic soluble fms-like tyrosine kinase 1 (sFlt1) and proangiogenic placental growth factor (PlGF) at presentation and examined for an association between the sFlt1/PlGF ratio and subsequent adverse maternal and perinatal outcomes within 2 weeks. The median sFlt1/PlGF ratio at presentation was elevated in participants who experienced any adverse outcome compared with those who did not (47.0 [25th-75th percentile, 15.5-112.2] versus 10.8 [25th-75th…
Citation impact
- FWCI
- 43.91
- Percentile
- 100%
- References
- 40
Authors
10- SRSarosh RanaCorresponding
National Institutes of Health, Beth Israel Deaconess Medical Center, Howard Hughes Medical Institute, Harvard University, Massachusetts General Hospital, Eunice Kennedy Shriver National Institute of Child Health and Human Development
- CECamille E. Powe
National Institutes of Health, Beth Israel Deaconess Medical Center, Howard Hughes Medical Institute, Harvard University, Massachusetts General Hospital, Eunice Kennedy Shriver National Institute of Child Health and Human Development
- SSSaira Salahuddin
National Institutes of Health, Beth Israel Deaconess Medical Center, Howard Hughes Medical Institute, Harvard University, Massachusetts General Hospital, Eunice Kennedy Shriver National Institute of Child Health and Human Development
- SVStefan Verlohren
National Institutes of Health, Beth Israel Deaconess Medical Center, Howard Hughes Medical Institute, Harvard University, Massachusetts General Hospital, Eunice Kennedy Shriver National Institute of Child Health and Human Development
- FHF. H. Perschel
National Institutes of Health, Beth Israel Deaconess Medical Center, Howard Hughes Medical Institute, Harvard University, Massachusetts General Hospital, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Topics & keywords
- Medicine
- Preeclampsia
- Hazard ratio
- Odds ratio
- Percentile
- Placental growth factor
- Proteinuria
- Confidence interval
- Good health and well-being