Development of Human Protein Reference Database as an Initial Platform for Approaching Systems Biology in Humans
Johns Hopkins University · University of Southern Denmark · +18 more institutions
Abstract
Human Protein Reference Database (HPRD) is an object database that integrates a wealth of information relevant to the function of human proteins in health and disease. Data pertaining to thousands of protein-protein interactions, posttranslational modifications, enzyme/substrate relationships, disease associations, tissue expression, and subcellular localization were extracted from the literature for a nonredundant set of 2750 human proteins. Almost all the information was obtained manually by biologists who read and interpreted >300,000 published articles during the annotation process. This database, which has an intuitive query interface allowing easy access to all the features of proteins, was built by…
Citation impact
- FWCI
- —
- Percentile
- —
- References
- 44
Authors
52- SPSuraj PeriCorresponding
Johns Hopkins University, University of Southern Denmark, Johns Hopkins Medicine
- JDJ. Daniel Navarro
Johns Hopkins University, Universidad de Navarra
- RARamars Amanchy
Johns Hopkins University
- TZTroels Zakarias Kristiansen
Johns Hopkins University, University of Southern Denmark
- CKChandra Kiran Jonnalagadda
Johns Hopkins University, Institute of Bioinformatics
Topics & keywords
- Annotation
- Biology
- Human proteins
- Database
- Function (biology)
- Protein structure database
- Computational biology
- Set (abstract data type)