articleNatureJun 6, 2007HYBRID OA

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

PRPaul R. BurtonDGDavid G. ClaytonLRLon R. CardonNCNick CraddockPDPanos Deloukas

University of Leicester · Juvenile Diabetes Research Foundation · +36 more institutions

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Abstract

There is increasing evidence that genome-wide association (GWA) studies represent a powerful approach to the identification of genes involved in common human diseases. We describe a joint GWA study (using the Affymetrix GeneChip 500K Mapping Array Set) undertaken in the British population, which has examined approximately 2,000 individuals for each of 7 major diseases and a shared set of approximately 3,000 controls. Case-control comparisons identified 24 independent association signals at P

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Authors

276
  • PR
    Paul R. BurtonCorresponding

    University of Leicester

  • DG
    David G. Clayton

    Juvenile Diabetes Research Foundation, Wellcome Trust

  • LR
    Lon R. Cardon

    Centre for Human Genetics, University of Oxford

  • NC
    Nick Craddock

    Cardiff University

  • PD
    Panos Deloukas

    Wellcome Sanger Institute

Topics & keywords

Topics
Keywords
  • Genome-wide association study
  • Genetics
  • Genetic association
  • Disease
  • Biology
  • Population
  • Odds ratio
  • Genome
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