Global Transcriptional Responses of Fission Yeast to Environmental Stress
Wellcome Sanger Institute · Cancer Research UK Manchester Institute · +1 more institution
Abstract
We explored transcriptional responses of the fission yeast Schizosaccharomyces pombe to various environmental stresses. DNA microarrays were used to characterize changes in expression profiles of all known and predicted genes in response to five stress conditions: oxidative stress caused by hydrogen peroxide, heavy metal stress caused by cadmium, heat shock caused by temperature increase to 39 degrees C, osmotic stress caused by sorbitol, and DNA damage caused by the alkylating agent methylmethane sulfonate. We define a core environmental stress response (CESR) common to all, or most, stresses. There was a substantial overlap between CESR genes of fission yeast and the genes of budding yeast that are…
Citation impact
- FWCI
- 16.03
- Percentile
- 100%
- References
- 50
Authors
9Topics & keywords
- Schizosaccharomyces pombe
- Biology
- Transcription factor
- Schizosaccharomyces
- Gene
- Cell biology
- Yeast
- Genetics