Early Discontinuation and Nonadherence to Adjuvant Hormonal Therapy in a Cohort of 8,769 Early-Stage Breast Cancer Patients
Kaiser Permanente · Cancer Prevention Institute of California · +1 more institution
Abstract
PURPOSE: While studies have found that adjuvant hormonal therapy for hormone-sensitive breast cancer (BC) dramatically reduces recurrence and mortality, adherence to medications is suboptimal. We investigated the rates and predictors of early discontinuation and nonadherence to hormonal therapy in patients enrolled in Kaiser Permanente of Northern California health system. PATIENTS AND METHODS: We identified women diagnosed with hormone-sensitive stage I-III BC from 1996 to 2007 and used automated pharmacy records to identify hormonal therapy prescriptions and dates of refill. We used Cox proportional hazards regression models to analyze factors associated with early discontinuation and nonadherence…
Citation impact
- FWCI
- 35.20
- Percentile
- 100%
- References
- 54
Authors
10- DLDawn L. HershmanCorresponding
Kaiser Permanente
- LHLawrence H. Kushi
Cancer Prevention Institute of California, Kaiser Permanente, Columbia University Irving Medical Center
- TSTheresa Shao
Cancer Prevention Institute of California, Kaiser Permanente, Columbia University Irving Medical Center
- DBDonna Buono
Cancer Prevention Institute of California, Kaiser Permanente, Columbia University Irving Medical Center
- AKAaron Kershenbaum
Cancer Prevention Institute of California, Kaiser Permanente, Columbia University Irving Medical Center
Topics & keywords
- Medicine
- Discontinuation
- Hormonal therapy
- Breast cancer
- Hazard ratio
- Hormone therapy
- Medical prescription
- Cancer
- Good health and well-being