articleProceedings of the National Academy of SciencesFeb 15, 2006GREEN OA

The HIV lipidome: A raft with an unusual composition

BBBritta BrüggerBGBärbel GlassPHPer HaberkantILIris LeibrechtFWFelix Wieland

Heidelberg University · University Hospital Heidelberg

PubMed
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Abstract

The lipids of enveloped viruses play critical roles in viral morphogenesis and infectivity. They are derived from the host membranes from which virus budding occurs, but the precise lipid composition has not been determined for any virus. Employing mass spectrometry, this study provides a quantitative analysis of the lipid constituents of HIV and a comprehensive comparison with its host membranes. Both a substantial enrichment of the unusual sphingolipid dihydrosphingomyelin and a loss of viral infectivity upon inhibition of sphingolipid biosynthesis in host cells are reported, establishing a critical role for this lipid class in the HIV replication cycle. Intriguingly, the overall lipid composition of native…

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Topics & keywords

Topics
Keywords
  • Lipidome
  • Lipid raft
  • Sphingolipid
  • Infectivity
  • Biology
  • Sphingomyelin
  • Lipidomics
  • Lipid microdomain
UN Sustainable Development Goals
  • Good health and well-being
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