Cell Death Pathways in Photodynamic Therapy of Cancer
Harvard University · Massachusetts General Hospital · +2 more institutions
Abstract
Photodynamic therapy (PDT) is an emerging cancer therapy that uses the combination of non-toxic dyes or photosensitizers (PS) and harmless visible light to produce reactive oxygen species and destroy tumors. The PS can be localized in various organelles such as mitochondria, lysosomes, endoplasmic reticulum, Golgi apparatus and plasma membranes and this sub-cellular location governs much of the signaling that occurs after PDT. There is an acute stress response that leads to changes in calcium and lipid metabolism and causes the production of cytokines and stress response mediators. Enzymes (particularly protein kinases) are activated and transcription factors are expressed. Many of the cellular responses…
Citation impact
- FWCI
- 14.80
- Percentile
- 100%
- References
- 146
Authors
4- PMPaweł MrózCorresponding
Harvard University, Massachusetts General Hospital
- AYAnastasia Yaroslavsky
Boston University, Massachusetts General Hospital
- GKGitika Kharkwal
Harvard University, Massachusetts General Hospital
- MRMichael R. Hamblin
Harvard University, Massachusetts General Hospital, Harvard–MIT Division of Health Sciences and Technology
Topics & keywords
- Autophagy
- Photodynamic therapy
- Programmed cell death
- Cell biology
- Endoplasmic reticulum
- Unfolded protein response
- Apoptosis
- Mitochondrion
- Good health and well-being