Update of the Stroke Therapy Academic Industry Roundtable Preclinical Recommendations
Harvard University · The University of Melbourne · +4 more institutions
Abstract
The initial Stroke Therapy Academic Industry Roundtable (STAIR) recommendations published in 1999 were intended to improve the quality of preclinical studies of purported acute stroke therapies. Although recognized as reasonable, they have not been closely followed nor rigorously validated. Substantial advances have occurred regarding the appropriate quality and breadth of preclinical testing for candidate acute stroke therapies for better clinical translation. The updated STAIR preclinical recommendations reinforce the previous suggestions that reproducibly defining dose response and time windows with both histological and functional outcomes in multiple animal species with appropriate physiological…
Citation impact
- FWCI
- 45.18
- Percentile
- 100%
- References
- 44
Authors
7- MFMarc FisherCorresponding
Harvard University, The University of Melbourne, University of Massachusetts Chan Medical School, Baylor College of Medicine, Cambridge Hospital, National Stroke Foundation
- GFGiora Feuerstein
Harvard University, The University of Melbourne, University of Massachusetts Chan Medical School, Baylor College of Medicine, Cambridge Hospital, National Stroke Foundation
- DWDavid W. Howells
Harvard University, The University of Melbourne, University of Massachusetts Chan Medical School, Baylor College of Medicine, Cambridge Hospital, National Stroke Foundation
- PDPatricia D. Hurn
Harvard University, The University of Melbourne, University of Massachusetts Chan Medical School, Baylor College of Medicine, Cambridge Hospital, National Stroke Foundation
- TAThomas A. Kent
Harvard University, The University of Melbourne, University of Massachusetts Chan Medical School, Baylor College of Medicine, Cambridge Hospital, National Stroke Foundation
Topics & keywords
- Medicine
- Stroke (engine)
- Clinical trial
- Preclinical research
- Intensive care medicine
- MEDLINE
- Clinical study design
- Inclusion and exclusion criteria