articleGutJun 22, 2012BRONZE OA

Intestinal microbiota in functional bowel disorders: a Rome foundation report

MSMagnus SimrénGBGiovanni BarbaraHJHarry J. FlintBSBrennan SpiegelRERobert E. Spiller

University of Gothenburg · University of Bologna · +11 more institutions

PubMed
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Abstract

It is increasingly perceived that gut host-microbial interactions are important elements in the pathogenesis of functional gastrointestinal disorders (FGID). The most convincing evidence to date is the finding that functional dyspepsia and irritable bowel syndrome (IBS) may develop in predisposed individuals following a bout of infectious gastroenteritis. There has been a great deal of interest in the potential clinical and therapeutic implications of small intestinal bacterial overgrowth in IBS. However, this theory has generated much debate because the evidence is largely based on breath tests which have not been validated. The introduction of culture-independent molecular techniques provides a major…

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Topics & keywords

Topics
Keywords
  • Irritable bowel syndrome
  • Synbiotics
  • Gut flora
  • Intestinal permeability
  • Dysbiosis
  • Functional gastrointestinal disorder
  • Antibiotics
  • Medicine
UN Sustainable Development Goals
  • Good health and well-being
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