Placebo-Induced Changes in fMRI in the Anticipation and Experience of Pain
University of Wisconsin–Madison · Harvard University · +5 more institutions
Abstract
The experience of pain arises from both physiological and psychological factors, including one's beliefs and expectations. Thus, placebo treatments that have no intrinsic pharmacological effects may produce analgesia by altering expectations. However, controversy exists regarding whether placebos alter sensory pain transmission, pain affect, or simply produce compliance with the suggestions of investigators. In two functional magnetic resonance imaging (fMRI) experiments, we found that placebo analgesia was related to decreased brain activity in pain-sensitive brain regions, including the thalamus, insula, and anterior cingulate cortex, and was associated with increased activity during anticipation of pain in…
Citation impact
- FWCI
- 53.24
- Percentile
- 100%
- References
- 36
Authors
9- TDTor D. WagerCorresponding
University of Wisconsin–Madison, Harvard University, Princeton University, University of Michigan, Veterans Health Administration, VA Center for Clinical Management Research, Ann Arbor VA Medical Center
- JKJames K. Rilling
University of Wisconsin–Madison, Harvard University, Princeton University, University of Michigan, Veterans Health Administration, VA Center for Clinical Management Research, Ann Arbor VA Medical Center
- EEEdward E. Smith
University of Wisconsin–Madison, Harvard University, Princeton University, University of Michigan, Veterans Health Administration, VA Center for Clinical Management Research, Ann Arbor VA Medical Center
- ASAlex Sokolik
University of Wisconsin–Madison, Harvard University, Princeton University, University of Michigan, Veterans Health Administration, VA Center for Clinical Management Research, Ann Arbor VA Medical Center
- KLKenneth L. Casey
University of Wisconsin–Madison, Harvard University, Princeton University, University of Michigan, Veterans Health Administration, VA Center for Clinical Management Research, Ann Arbor VA Medical Center
Topics & keywords
- Placebo
- Functional magnetic resonance imaging
- Anticipation (artificial intelligence)
- Anterior cingulate cortex
- Insula
- Psychology
- Cingulate cortex
- Thalamus
- Good health and well-being