The epidemiology of glioma in adults: a "state of the science" review

Gliomas are the most common primary intracranial tumor, representing 81% of malignant brain tumors. Although relatively rare, they cause significant mortality and morbidity. Glioblastoma, the most common glioma histology (∼45% of all gliomas), has a 5-year relative survival of ∼5%. A small portion of these tumors are caused by Mendelian disorders, including neurofibromatosis, tuberous sclerosis, and Li-Fraumeni syndrome. Genomic analyses of glioma have also produced new evidence about risk and prognosis. Recently discovered biomarkers that indicate improved survival include O⁶-methylguanine-DNA methyltransferase methylation, isocitrate dehydrogenase mutation, and a glioma cytosine-phosphate-guanine island…

• CC
  Case Comprehensive Cancer Center, Case Western Reserve University

  Awards: P30 CA043703, CA043703
• GO
  Government of Canada
• NI
  National Institutes of Health

  Awards: P30 CA043703, CA043703
• NC
  National Cancer Institute

  Awards: P30 CA043703, CA043703