antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences
University of Groningen · TH Bingen University of Applied Sciences · +7 more institutions
Abstract
Bacterial and fungal secondary metabolism is a rich source of novel bioactive compounds with potential pharmaceutical applications as antibiotics, anti-tumor drugs or cholesterol-lowering drugs. To find new drug candidates, microbiologists are increasingly relying on sequencing genomes of a wide variety of microbes. However, rapidly and reliably pinpointing all the potential gene clusters for secondary metabolites in dozens of newly sequenced genomes has been extremely challenging, due to their biochemical heterogeneity, the presence of unknown enzymes and the dispersed nature of the necessary specialized bioinformatics tools and resources. Here, we present antiSMASH (antibiotics & Secondary Metabolite…
Citation impact
- FWCI
- 73.28
- Percentile
- 100%
- References
- 31
Authors
9- MHMarnix H. MedemaCorresponding
University of Groningen
- KBKai Blin
TH Bingen University of Applied Sciences, University of Tübingen
- PCPeter Cimermančič
QB3, University of California, San Francisco
- VDVictor de Jager
Radboud University Nijmegen, Wageningen University & Research
- PZPiotr Zakrzewski
University of Groningen, Microbial ID (United States)
Topics & keywords
- Biology
- Genome
- Gene cluster
- Gene
- Secondary metabolite
- Computational biology
- Secondary metabolism
- Bacterial genome size