Tumor necrosis factor-α triggers a cytokine cascade yielding postoperative cognitive decline
University of California, San Francisco · Chelsea and Westminster Hospital · +1 more institution
Abstract
Cognitive decline following surgery in older individuals is a major clinical problem of uncertain mechanism; a similar cognitive decline also follows severe infection, chemotherapy, or trauma and is currently without effective therapy. A variety of mechanisms have been proposed, and exploring the role of inflammation, we recently reported the role of IL-1β in the hippocampus after surgery in mice with postoperative cognitive dysfunction. Here, we show that TNF-α is upstream of IL-1 and provokes its production in the brain. Peripheral blockade of TNF-α is able to limit the release of IL-1 and prevent neuroinflammation and cognitive decline in a mouse model of surgery-induced cognitive decline. TNF-α appears to…
Citation impact
- FWCI
- 18.72
- Percentile
- 100%
- References
- 53
Authors
6- NTNiccolò TerrandoCorresponding
University of California, San Francisco, Chelsea and Westminster Hospital, Imperial College London
- CMClaudia Monaco
Imperial College London
- DMDaqing Ma
Chelsea and Westminster Hospital, Imperial College London
- BMBrian M. J. Foxwell
Imperial College London
- MFMarc Feldmann
Imperial College London
Topics & keywords
- Cognitive decline
- Neuroinflammation
- Postoperative cognitive dysfunction
- Cognition
- Inflammation
- Tumor necrosis factor alpha
- Medicine
- Cytokine