articleClinical Cancer ResearchAug 26, 2009BRONZE OA

Salivary microRNA: Discovery, Characterization, and Clinical Utility for Oral Cancer Detection

NJNoh Jin ParkHZHui ZhouDEDavid ElashoffBSBradley S. HensonDKDragana Kastratović

University of California, Los Angeles

PubMed
Indexed incrossrefpubmed

Abstract

PURPOSE: We have previously shown that a transcriptome is found in saliva and subpanels of these mRNAs can be used as oral cancer biomarkers. In this study, we measured the presence of microRNAs (miRNA) in saliva and determined their potential as an additional set of oral cancer biomarkers. EXPERIMENTAL DESIGN: A total of 314 miRNAs were measured using reverse transcriptase-preamplification-quantitative PCR in 12 healthy controls. Degradation pattern of endogenous and exogenous saliva miRNAs were measured at room temperature over time. Selected miRNAs were validated in saliva of 50 oral squamous cell carcinoma patients and 50 healthy matched control subjects. RESULTS: We detected approximately 50 miRNAs in…

Citation impact

836
total citations
FWCI
16.01
Percentile
100%
References
38
Citations per year

Authors

7

Topics & keywords

Topics
Keywords
  • Saliva
  • microRNA
  • Cancer
  • Transcriptome
  • Endogeny
  • Biology
  • Basal cell
  • Cancer research
UN Sustainable Development Goals
  • Good health and well-being
No related works found for this paper.

Funding