reviewHuman Molecular GeneticsApr 15, 2010BRONZE OA

Molecular mechanisms of neurodegeneration in Alzheimer's disease

LCLeslie CrewsEMEliezer Masliah

University of California, San Diego

PubMed
Indexed incrossrefpubmed

Abstract

Alzheimer's disease (AD) is characterized by cognitive impairment, progressive neurodegeneration and formation of amyloid-beta (Abeta)-containing plaques and neurofibrillary tangles composed of hyperphosphorylated tau. The neurodegenerative process in AD is initially characterized by synaptic damage accompanied by neuronal loss. In addition, recent evidence suggests that alterations in adult neurogenesis in the hippocampus might play a role. Synaptic loss is one of the strongest correlates to the cognitive impairment in patients with AD. Several lines of investigation support the notion that the synaptic pathology and defective neurogenesis in AD are related to progressive accumulation of Abeta oligomers…

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Authors

2

Topics & keywords

Topics
Keywords
  • Neurodegeneration
  • Neurogenesis
  • Biology
  • GSK-3
  • Neuroscience
  • Synaptic plasticity
  • Cyclin-dependent kinase 5
  • Cell biology
UN Sustainable Development Goals
  • Good health and well-being
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