One-Year Brain Atrophy Evident in Healthy Aging
University of Oslo · University of California San Diego
Abstract
An accurate description of changes in the brain in healthy aging is needed to understand the basis of age-related changes in cognitive function. Cross-sectional magnetic resonance imaging (MRI) studies suggest thinning of the cerebral cortex, volumetric reductions of most subcortical structures, and ventricular expansion. However, there is a paucity of detailed longitudinal studies to support the cross-sectional findings. In the present study, 142 healthy elderly participants (60-91 years of age) were followed with repeated MRI, and were compared with 122 patients with mild to moderate Alzheimer's disease (AD). Volume changes were measured across the entire cortex and in 48 regions of interest. Cortical…
Citation impact
- FWCI
- 12.86
- Percentile
- 100%
- References
- 72
Authors
8Topics & keywords
- Atrophy
- Magnetic resonance imaging
- Neuroscience
- Medicine
- Brain size
- Cerebral cortex
- Disease
- Cortex (anatomy)
Funding
- FFFoundation for the National Institutes of HealthAwards: Grant U01 AG024904, AG024904, U01 AG024904
- AAAlzheimer's AssociationAward: U01 AG024904
- BSBristol-Myers SquibbAwards: U01 AG024904, AG024904
- ELEli Lilly and CompanyAwards: U01 AG024904, AG024904
- PPfizerAwards: AG024904, U01 AG024904
- AAstraZeneca
- GGlaxoSmithKline
- ADAlzheimer's Disease Neuroimaging InitiativeAwards: AG024904, U01 AG024904
- NCNorthern California Institute for Research and EducationAward: U01 AG024904
- EEisaiAwards: U01 AG024904, AG024904
- NFNorges Forskningsråd
- NINational Institutes of HealthAwards: AG024904, K01AG029218, U01 AG024904, U24 RR021382, Grant U01 AG024904, R01 AG031224
- UFU.S. Food and Drug Administration
- UOUniversity of California, Los Angeles
- UOUniversity of California, San Diego
- NINational Institute on AgingAwards: U01 AG024904, U24 RR021382, K01AG029218, AG024904
- NINational Institute of Biomedical Imaging and BioengineeringAwards: U24 RR021382, U01 AG024904, K01AG029218, AG024904
- NCNational Center for Research ResourcesAwards: K01AG029218, U01 AG024904, U24 RR021382