Genetic Mapping in Human Disease
Broad Institute · Harvard University · +4 more institutions
Abstract
Genetic mapping provides a powerful approach to identify genes and biological processes underlying any trait influenced by inheritance, including human diseases. We discuss the intellectual foundations of genetic mapping of Mendelian and complex traits in humans, examine lessons emerging from linkage analysis of Mendelian diseases and genome-wide association studies of common diseases, and discuss questions and challenges that lie ahead.
Citation impact
- FWCI
- 102.06
- Percentile
- 100%
- References
- 167
Authors
3- DADavid AltshulerCorresponding
Broad Institute, Harvard University, Massachusetts General Hospital, Center for Human Genetics
- MJMark J. DalyCorresponding
Broad Institute, Harvard University, Massachusetts General Hospital, Center for Human Genetics
- ESEric S. LanderCorresponding
Broad Institute, Harvard University, Massachusetts General Hospital, Center for Human Genetics, Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology
Topics & keywords
- Mendelian inheritance
- Inheritance (genetic algorithm)
- Trait
- Biology
- OMIM : Online Mendelian Inheritance in Man
- Genetic association
- Genome-wide association study
- Genetics