Janus-faced microglia: beneficial and detrimental consequences of microglial phagocytosis
University of the Basque Country · Ikerbasque · +2 more institutions
Abstract
Microglia are the resident brain macrophages and they have been traditionally studied as orchestrators of the brain inflammatory response during infections and disease. In addition, microglia has a more benign, less explored role as the brain professional phagocytes. Phagocytosis is a term coined from the Greek to describe the receptor-mediated engulfment and degradation of dead cells and microbes. In addition, microglia phagocytoses brain-specific cargo, such as axonal and myelin debris in spinal cord injury or multiple sclerosis, amyloid-β deposits in Alzheimer's disease, and supernumerary synapses in postnatal development. Common mechanisms of recognition, engulfment, and degradation of the different types…
Citation impact
- FWCI
- 30.34
- Percentile
- 100%
- References
- 267
Authors
4Topics & keywords
- Microglia
- Phagocytosis
- Neuroscience
- Biology
- Neuroinflammation
- TREM2
- Multiple sclerosis
- Cell biology