Iron neurochemistry in Alzheimer's disease and Parkinson's disease: targets for therapeutics
The University of Melbourne · Florey Institute of Neuroscience and Mental Health
Abstract
Brain iron homeostasis is increasingly recognized as a potential target for the development of drug therapies for aging-related disorders. Dysregulation of iron metabolism associated with cellular damage and oxidative stress is reported as a common event in several neurodegenerative disorders such as Alzheimer's, Parkinson's, and Huntington's diseases. Indeed, many proteins initially characterized in those diseases such as amyloid-β protein, α-synuclein, and huntingtin have been linked to iron neurochemistry. Iron plays a crucial role in maintaining normal physiological functions in the brain through its participation in many cellular functions such as mitochondrial respiration, myelin synthesis, and…
Citation impact
- FWCI
- 22.43
- Percentile
- 100%
- References
- 234
Authors
2Topics & keywords
- Neurodegeneration
- Neuroscience
- Neurochemistry
- Oxidative stress
- Parkinson's disease
- Biology
- Disease
- Medicine
- Good health and well-being