The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance
Centre for Human Genetics · John Radcliffe Hospital · +5 more institutions
Abstract
The role of autophagy, a lysosomal degradation pathway which prevents cellular damage, in the maintenance of adult mouse hematopoietic stem cells (HSCs) remains unknown. Although normal HSCs sustain life-long hematopoiesis, malignant transformation of HSCs leads to leukemia. Therefore, mechanisms protecting HSCs from cellular damage are essential to prevent hematopoietic malignancies. In this study, we crippled autophagy in HSCs by conditionally deleting the essential autophagy gene Atg7 in the hematopoietic system. This resulted in the loss of normal HSC functions, a severe myeloproliferation, and death of the mice within weeks. The hematopoietic stem and progenitor cell compartment displayed an accumulation…
Citation impact
- FWCI
- 26.24
- Percentile
- 100%
- References
- 67
Authors
12- MMMonika Mortensen
Centre for Human Genetics, John Radcliffe Hospital, National Institute for Health and Care Research, University of Oxford, Nuffield Health, Institute of Molecular Medicine
- EJElizabeth J. Soilleux
Centre for Human Genetics, John Radcliffe Hospital, National Institute for Health and Care Research, University of Oxford, Nuffield Health, Institute of Molecular Medicine
- GDGordana Djordjević
Centre for Human Genetics, John Radcliffe Hospital, National Institute for Health and Care Research, University of Oxford, Nuffield Health, Institute of Molecular Medicine
- RTRebecca Tripp
Centre for Human Genetics, John Radcliffe Hospital, National Institute for Health and Care Research, University of Oxford, Nuffield Health, Institute of Molecular Medicine
- MLMichael Lutteropp
Centre for Human Genetics, John Radcliffe Hospital, National Institute for Health and Care Research, University of Oxford, Nuffield Health, Institute of Molecular Medicine
Topics & keywords
- Haematopoiesis
- Autophagy
- Stem cell
- Biology
- Cell biology
- Progenitor cell
- Hematopoietic stem cell
- Myeloid
- Responsible consumption and production