Mitochondrial calcium overload is a key determinant in heart failure

Calcium (Ca2+) released from the sarcoplasmic reticulum (SR) is crucial for excitation-contraction (E-C) coupling. Mitochondria, the major source of energy, in the form of ATP, required for cardiac contractility, are closely interconnected with the SR, and Ca2+ is essential for optimal function of these organelles. However, Ca2+ accumulation can impair mitochondrial function, leading to reduced ATP production and increased release of reactive oxygen species (ROS). Oxidative stress contributes to heart failure (HF), but whether mitochondrial Ca2+ plays a mechanistic role in HF remains unresolved. Here, we show for the first time, to our knowledge, that diastolic SR Ca2+ leak causes mitochondrial Ca2+ overload…

• AH
  American Heart Association

  Awards: 13POST16810041, 13POST16810041 and 15SDG25300007
• UO
  University of Washington
• FL
  Fondation Leducq
• IN
  Institut National de la Santé et de la Recherche Médicale
• UD
  Université de Montpellier
• NI
  National Institutes of Health

  Award: R01HL061503
• NH
  National Heart, Lung, and Blood Institute

  Award: R01HL061503