Chronic Stress Induces Contrasting Patterns of Dendritic Remodeling in Hippocampal and Amygdaloid Neurons
National Centre for Biological Sciences · Tata Institute of Fundamental Research
Abstract
The hippocampus and the amygdala are essential components of the neural circuitry mediating stress responses. The hippocampus, which provides negative feedback regulation of the stress response, is particularly vulnerable to degenerative changes caused by chronic stress. Unlike the hippocampus, relatively little is known about how stress affects the amygdala and the nature of its role in the stress response. Hence, we examined the effects of two different models of chronic stress on hippocampal and amygdaloid neuronal morphology in rats. In agreement with previous reports, chronic immobilization stress (CIS) induced dendritic atrophy and debranching in CA3 pyramidal neurons of the hippocampus. In striking…
Citation impact
- FWCI
- 8.38
- Percentile
- 100%
- References
- 54
Authors
4- AVAjai VyasCorresponding
National Centre for Biological Sciences, Tata Institute of Fundamental Research
- RMRupshi Mitra
Tata Institute of Fundamental Research, National Centre for Biological Sciences
- BSB.S. Shankaranarayana Rao
National Centre for Biological Sciences, Tata Institute of Fundamental Research
- SCSumantra Chattarji
Tata Institute of Fundamental Research, National Centre for Biological Sciences
Topics & keywords
- Amygdala
- Hippocampus
- Neuroscience
- Chronic stress
- Hippocampal formation
- Basolateral amygdala
- Neuroplasticity
- Psychology