Integrative Transcriptome Analysis Reveals Common Molecular Subclasses of Human Hepatocellular Carcinoma
Broad Institute · Harvard University · +11 more institutions
Abstract
Hepatocellular carcinoma (HCC) is a highly heterogeneous disease, and prior attempts to develop genomic-based classification for HCC have yielded highly divergent results, indicating difficulty in identifying unified molecular anatomy. We performed a meta-analysis of gene expression profiles in data sets from eight independent patient cohorts across the world. In addition, aiming to establish the real world applicability of a classification system, we profiled 118 formalin-fixed, paraffin-embedded tissues from an additional patient cohort. A total of 603 patients were analyzed, representing the major etiologies of HCC (hepatitis B and C) collected from Western and Eastern countries. We observed three robust…
Citation impact
- FWCI
- 16.32
- Percentile
- 100%
- References
- 41
Authors
16- YHYujin HoshidaCorresponding
Broad Institute, Harvard University, Dana-Farber Cancer Institute, Massachusetts Institute of Technology
- SNSebastian Nijman
Broad Institute, Harvard University, Austrian Academy of Sciences, Massachusetts Institute of Technology
- MKMasahiro Kobayashi
Toranomon Hospital
- JAJennifer A. Chan
Broad Institute, Harvard University, University of Calgary, Massachusetts Institute of Technology
- JBJean-Philippe Brunet
Broad Institute, Harvard University, Massachusetts Institute of Technology
Topics & keywords
- Wnt signaling pathway
- Hepatocellular carcinoma
- Transcriptome
- Cancer research
- Biology
- Gene
- Cancer
- Computational biology
- Partnerships for the goals