Persistent Chronic Inflammation and Infection by Chikungunya Arthritogenic Alphavirus in Spite of a Robust Host Immune Response
University of Reunion Island · Centre Hospitalier Universitaire de La Réunion · +15 more institutions
Abstract
Alphaviruses, including Chikungunya virus (CHIKV), produce a transient illness in humans, but severe forms leading to chronic incapacitating arthralgia/arthritis have been reported by mechanisms largely ill-characterized. The pathogenesis of CHIKV was addressed in a prospective cohort study of 49 hospitalized patients from Reunion Island subsequently categorized into two distinct groups at 12 mo postinfection. Comprehensive analyses of the clinical and immunological parameters throughout the disease course were analyzed in either the "recovered" or the "chronic" groups to identify prognostic markers of arthritis-like pathology after CHIKV disease. We found that the chronic group consisted mainly of more…
Citation impact
- FWCI
- 27.42
- Percentile
- 100%
- References
- 58
Authors
25- JHJean‐Jacques HoarauCorresponding
University of Reunion Island, Centre Hospitalier Universitaire de La Réunion, Department of Virology, Écologie Marine Tropicale des Océans Pacifique et Indien, Institute of Virology of the Slovak Academy of Sciences
- MJMarie-Christine Jaffar Bandjee
University of Reunion Island, Centre Hospitalier Universitaire de La Réunion, Department of Virology, Laboratoire de Microbiologie et Génétique Moléculaires, Écologie Marine Tropicale des Océans Pacifique et Indien, Institute of Virology of the Slovak Academy of Sciences
- PKPascale Krejbich‐Trotot
University of Reunion Island, Centre Hospitalier Universitaire de La Réunion, Laboratoire de Microbiologie et Génétique Moléculaires, Écologie Marine Tropicale des Océans Pacifique et Indien
- TDTrina Das
University of Reunion Island, Centre Hospitalier Universitaire de La Réunion, Laboratoire de Microbiologie et Génétique Moléculaires, Écologie Marine Tropicale des Océans Pacifique et Indien
- GLGhislaine Li-Pat-Yuen
Department of Virology, Institute of Virology of the Slovak Academy of Sciences
Topics & keywords
- Immunology
- Immune system
- Arthritis
- CD8
- Medicine
- Chikungunya
- Pathogenesis
- Inflammation
- Good health and well-being