articleAntimicrobial Agents and ChemotherapySep 21, 2009GREEN OA

Characterization of a New Metallo-β-Lactamase Gene, bla NDM-1 , and a Novel Erythromycin Esterase Gene Carried on a Unique Genetic Structure in Klebsiella pneumoniae Sequence Type 14 from India

DYDongeun YongMAMark A. TolemanCGChristian G. GiskeHSHyun S. ChoKSKristina Sundman

Yonsei University · Cardiff University · +3 more institutions

PubMed
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Abstract

A Swedish patient of Indian origin traveled to New Delhi, India, and acquired a urinary tract infection caused by a carbapenem-resistant Klebsiella pneumoniae strain that typed to the sequence type 14 complex. The isolate, Klebsiella pneumoniae 05-506, was shown to possess a metallo-beta-lactamase (MBL) but was negative for previously known MBL genes. Gene libraries and amplification of class 1 integrons revealed three resistance-conferring regions; the first contained bla(CMY-4) flanked by ISEcP1 and blc. The second region of 4.8 kb contained a complex class 1 integron with the gene cassettes arr-2, a new erythromycin esterase gene; ereC; aadA1; and cmlA7. An intact ISCR1 element was shown to be downstream…

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Topics & keywords

Topics
Keywords
  • Klebsiella pneumoniae
  • Integron
  • Biology
  • Gene
  • Microbiology
  • Genetics
  • Insertion sequence
  • Erythromycin
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