Epigenome-Wide Scans Identify Differentially Methylated Regions for Age and Age-Related Phenotypes in a Healthy Ageing Population
Centre for Human Genetics · University of Oxford · +8 more institutions
Abstract
Age-related changes in DNA methylation have been implicated in cellular senescence and longevity, yet the causes and functional consequences of these variants remain unclear. To elucidate the role of age-related epigenetic changes in healthy ageing and potential longevity, we tested for association between whole-blood DNA methylation patterns in 172 female twins aged 32 to 80 with age and age-related phenotypes. Twin-based DNA methylation levels at 26,690 CpG-sites showed evidence for mean genome-wide heritability of 18%, which was supported by the identification of 1,537 CpG-sites with methylation QTLs in cis at FDR 5%. We performed genome-wide analyses to discover differentially methylated regions (DMRs) for…
Citation impact
- FWCI
- 31.44
- Percentile
- 100%
- References
- 58
Authors
22Topics & keywords
- Differentially methylated regions
- Biology
- DNA methylation
- Epigenome
- Epigenetics
- Methylation
- CpG site
- Genetics