Quantitation and mapping of tissue optical properties using modulated imaging
Modulim (United States) · University of California, Irvine
Abstract
We describe the development of a rapid, noncontact imaging method, modulated imaging (MI), for quantitative, wide-field characterization of optical absorption and scattering properties of turbid media. MI utilizes principles of frequency-domain sampling and model-based analysis of the spatial modulation transfer function (s-MTF). We present and compare analytic diffusion and probabilistic Monte Carlo models of diffuse reflectance in the spatial frequency domain. Next, we perform MI measurements on tissue-simulating phantoms exhibiting a wide range of l values (0.5 mm to 3 mm) and (micro(s) (')micro(a)) ratios (8 to 500), reporting an overall accuracy of approximately 6% and 3% in absorption and reduced…
Citation impact
- FWCI
- 18.83
- Percentile
- 100%
- References
- 34
Authors
5Topics & keywords
- Optical imaging
- Materials science
- Medical imaging
- Diffuse optical imaging
- Optics
- Biomedical engineering
- Computer science
- Tomography