RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement

Lau, Christina M.; Broughton, Courtney; Tabor, Abigail S.; Akira, Shizuo; Flavell, Richard A.; Mamula, Mark J.; Christensen, Sean R.; Shlomchik, Mark J.; Viglianti, Gregory A.; Rifkin, Ian R.; Marshak‐Rothstein, Ann

doi:10.1084/jem.20050630

articleThe Journal of Experimental MedicineOct 31, 2005BRONZE OA

RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement

CMChristina M. Lau CBCourtney Broughton ASAbigail S. Tabor SAShizuo Akira RARichard A. Flavell

Boston University · The University of Osaka · +2 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Previous studies (Leadbetter, E.A., I.R. Rifkin, A.H. Hohlbaum, B. Beaudette, M.J. Shlomchik, and A. Marshak-Rothstein. 2002. Nature. 416:603-607; Viglianti, G.A., C.M. Lau, T.M. Hanley, B.A. Miko, M.J. Shlomchik, and A. Marshak-Rothstein. 2003. Immunity. 19:837-847) established the unique capacity of DNA and DNA-associated autoantigens to activate autoreactive B cells via sequential engagement of the B cell antigen receptor (BCR) and Toll-like receptor (TLR) 9. We demonstrate that this two-receptor paradigm can be extended to the BCR/TLR7 activation of autoreactive B cells by RNA and RNA-associated autoantigens. These data implicate TLR recognition of endogenous ligands in the response to both DNA- and…

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800

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FWCI: 19.57
Percentile: 100%
References: 32

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Authors

11

Topics & keywords

Topics

Keywords

TLR7
B-cell receptor
Biology
Autoantibody
Immunology
Toll-like receptor
RNA
TLR9

UN Sustainable Development Goals

Good health and well-being

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