Stem Cell Properties of Human Dental Pulp Stem Cells
University of California, San Francisco · National Institute of Dental and Craniofacial Research · +2 more institutions
Abstract
In this study, we characterized the self-renewal capability, multi-lineage differentiation capacity, and clonogenic efficiency of human dental pulp stem cells (DPSCs). DPSCs were capable of forming ectopic dentin and associated pulp tissue in vivo. Stromal-like cells were reestablished in culture from primary DPSC transplants and re-transplanted into immunocompromised mice to generate a dentin-pulp-like tissue, demonstrating their self-renewal capability. DPSCs were also found to be capable of differentiating into adipocytes and neural-like cells. The odontogenic potential of 12 individual single-colony-derived DPSC strains was determined. Two-thirds of the single-colony-derived DPSC strains generated abundant…
Citation impact
- FWCI
- 10.77
- Percentile
- 100%
- References
- 24
Authors
9- SGStan GronthosCorresponding
University of California, San Francisco, National Institute of Dental and Craniofacial Research, Florida Craniofacial Institute, University College London
- JSJaime S. Brahim
University of California, San Francisco, National Institute of Dental and Craniofacial Research, Florida Craniofacial Institute, University College London
- WLW. Li
University of California, San Francisco, National Institute of Dental and Craniofacial Research, Florida Craniofacial Institute, University College London
- LWLarry W. Fisher
University of California, San Francisco, National Institute of Dental and Craniofacial Research, Florida Craniofacial Institute, University College London
- NCNatasha Cherman
University of California, San Francisco, National Institute of Dental and Craniofacial Research, Florida Craniofacial Institute, University College London
Topics & keywords
- Dental pulp stem cells
- Pulp (tooth)
- Stem cell
- Dentin
- Odontoblast
- Cell biology
- Biology
- Stromal cell