articleBritish Journal of CancerJun 8, 2004HYBRID OA

The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website

SBSally BamfordEDElisabeth DawsonSFSimon ForbesJCJody ClementsRPRoger Pettett

Wellcome Sanger Institute · Wellcome Trust · +4 more institutions

PubMed
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Abstract

The discovery of mutations in cancer genes has advanced our understanding of cancer. These results are dispersed across the scientific literature and with the availability of the human genome sequence will continue to accrue. The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website have been developed to store somatic mutation data in a single location and display the data and other information related to human cancer. To populate this resource, data has currently been extracted from reports in the scientific literature for somatic mutations in four genes, BRAF, HRAS, KRAS2 and NRAS. At present, the database holds information on 66 634 samples and reports a total of 10 647 mutations. Through…

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Topics & keywords

Topics
Keywords
  • HRAS
  • Neuroblastoma RAS viral oncogene homolog
  • COSMIC cancer database
  • Somatic cell
  • Genome
  • Germline mutation
  • Mutation
  • Biology
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