Identification of a B cell signature associated with renal transplant tolerance in humans

Establishing long-term allograft acceptance without the requirement for continuous immunosuppression, a condition known as allograft tolerance, is a highly desirable therapeutic goal in solid organ transplantation. Determining which recipients would benefit from withdrawal or minimization of immunosuppression would be greatly facilitated by biomarkers predictive of tolerance. In this study, we identified the largest reported cohort to our knowledge of tolerant renal transplant recipients, as defined by stable graft function and receiving no immunosuppression for more than 1 year, and compared their gene expression profiles and peripheral blood lymphocyte subsets with those of subjects with stable graft…

• KC
  King's College Hospital NHS Foundation Trust
• NI
  National Institute for Health and Care Research
• KC
  King's College London
• UO
  University of California, San Francisco
• MR
  Medical Research Council

  Award: G0801537/ID: 88245
• NI
  National Institute of Allergy and Infectious Diseases