Suppression of non-small cell lung tumor development by the let-7 microRNA family

Many microRNAs (miRNAs) target mRNAs involved in processes aberrant in tumorigenesis, such as proliferation, survival, and differentiation. In particular, the let-7 miRNA family has been proposed to function in tumor suppression, because reduced expression of let-7 family members is common in non-small cell lung cancer (NSCLC). Here, we show that let-7 functionally inhibits non-small cell tumor development. Ectopic expression of let-7g in K-Ras(G12D)-expressing murine lung cancer cells induced both cell cycle arrest and cell death. In tumor xenografts, we observed significant growth reduction of both murine and human non-small cell lung tumors when overexpression of let-7g was induced from lentiviral vectors.…

• NS
  National Science Foundation

  Awards: CA42063, P30-CA14051
• MI
  Massachusetts Institute of Technology

  Award: P30-CA14051
• KK
  KWF Kankerbestrijding
• NI
  National Institutes of Health

  Awards: GM34277, RO1-GM34277, P30-CA14051, CA42063, CA112967
• UP
  U.S. Public Health Service

  Awards: P30-CA14051, RO1-GM34277, CA42063
• NC
  National Cancer Institute

  Awards: U54 CA112967, P30-CA14051, CA14051, CA42063, PO1-CA42063