Suppression of Aging in Mice by the Hormone Klotho
Vanderbilt University · Southwestern Medical Center · +3 more institutions
Abstract
A defect in Klotho gene expression in mice accelerates the degeneration of multiple age-sensitive traits. Here, we show that overexpression of Klotho in mice extends life span. Klotho protein functions as a circulating hormone that binds to a cell-surface receptor and represses intracellular signals of insulin and insulin-like growth factor 1 (IGF1), an evolutionarily conserved mechanism for extending life span. Alleviation of aging-like phenotypes in Klotho-deficient mice was observed by perturbing insulin and IGF1 signaling, suggesting that Klotho-mediated inhibition of insulin and IGF1 signaling contributes to its anti-aging properties. Klotho protein may function as an anti-aging hormone in mammals.
Citation impact
- FWCI
- 32.75
- Percentile
- 100%
- References
- 29
Authors
16- HKHiroshi KurosuCorresponding
Vanderbilt University, Southwestern Medical Center, The University of Tokyo, The University of Texas Southwestern Medical Center, The University of Osaka
- MYMasaya Yamamoto
Vanderbilt University, Southwestern Medical Center, The University of Tokyo, The University of Texas Southwestern Medical Center, The University of Osaka
- JDJeremy D. Clark
Vanderbilt University, Southwestern Medical Center, The University of Tokyo, The University of Texas Southwestern Medical Center, The University of Osaka
- JVJohanne V. Pastor
Vanderbilt University, Southwestern Medical Center, The University of Tokyo, The University of Texas Southwestern Medical Center, The University of Osaka
- ANAnimesh Nandi
Vanderbilt University, Southwestern Medical Center, The University of Tokyo, The University of Texas Southwestern Medical Center, The University of Osaka
Topics & keywords
- Klotho
- Endocrinology
- Internal medicine
- Insulin
- Biology
- Hormone
- Insulin receptor
- Cell biology