SIFT web server: predicting effects of amino acid substitutions on proteins
Genome Institute of Singapore · J. Craig Venter Institute · +6 more institutions
Abstract
The Sorting Intolerant from Tolerant (SIFT) algorithm predicts the effect of coding variants on protein function. It was first introduced in 2001, with a corresponding website that provides users with predictions on their variants. Since its release, SIFT has become one of the standard tools for characterizing missense variation. We have updated SIFT's genome-wide prediction tool since our last publication in 2009, and added new features to the insertion/deletion (indel) tool. We also show accuracy metrics on independent data sets. The original developers have hosted the SIFT web server at FHCRC, JCVI and the web server is currently located at BII. The URL is http://sift-dna.org (24 May 2012, date last…
Citation impact
- FWCI
- 37.41
- Percentile
- 100%
- References
- 40
Authors
6- NSNgak-Leng SimCorresponding
Genome Institute of Singapore
- PNP. Naresh Kumar
J. Craig Venter Institute
- JHJing Hu
Franklin & Marshall College
- SHSteven Henikoff
Howard Hughes Medical Institute, Fred Hutch Cancer Center, Cancer Research Center, Hutchinson (United Kingdom)
- GSGeorg Schneider
Bioinformatics Institute
Topics & keywords
- Scale-invariant feature transform
- Indel
- Biology
- Web server
- Computational biology
- The Internet
- Computer science
- Missense mutation