NOD/SCID/γcnull mouse: an excellent recipient mouse model for engraftment of human cells
Tokai University · Gunma University · +3 more institutions
Abstract
To establish a more appropriate animal recipient for xenotransplantation, NOD/SCID/gamma(c)(null) mice double homozygous for the severe combined immunodeficiency (SCID) mutation and interleukin-2Rgamma (IL-2Rgamma) allelic mutation (gamma(c)(null)) were generated by 8 backcross matings of C57BL/6J-gamma(c)(null) mice and NOD/Shi-scid mice. When human CD34+ cells from umbilical cord blood were transplanted into this strain, the engraftment rate in the peripheral circulation, spleen, and bone marrow were significantly higher than that in NOD/Shi-scid mice treated with anti-asialo GM1 antibody or in the beta2-microglobulin-deficient NOD/LtSz-scid (NOD/SCID/beta2m(null)) mice, which were as completely defective in…
Citation impact
- FWCI
- 4.48
- Percentile
- 100%
- References
- 29
Authors
12- MIMamoru ItoCorresponding
Tokai University, Gunma University, Tohoku University, Central Institute for Experimental Animals, Kyoto University
- HHHidefumi Hiramatsu
Tokai University, Gunma University, Tohoku University, Central Institute for Experimental Animals, Kyoto University
- KKKimio Kobayashi
Tokai University, Gunma University, Tohoku University, Central Institute for Experimental Animals, Kyoto University
- KSKazutomo Suzue
Tokai University, Gunma University, Tohoku University, Central Institute for Experimental Animals, Kyoto University
- MKMariko Kawahata
Tokai University, Gunma University, Tohoku University, Central Institute for Experimental Animals, Kyoto University
Topics & keywords
- Nod
- Severe combined immunodeficiency
- Biology
- Immunology
- Cancer research
- Medicine
- Gene
- Genetics