Greater Clinical Benefit of More Intensive Oral Antiplatelet Therapy With Prasugrel in Patients With Diabetes Mellitus in the Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition With Prasugrel–Thrombolysis in Myocardial Infarction 38
St. Michael's Hospital · Radboud University Nijmegen · +7 more institutions
Abstract
BACKGROUND: Patients with diabetes mellitus (DM) are at high risk for recurrent cardiovascular events after acute coronary syndromes, in part because of increased platelet reactivity. The Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition With Prasugrel-Thrombolysis in Myocardial Infarction 38 (TRITON-TIMI 38) showed an overall reduction in ischemic events with more intensive antiplatelet therapy with prasugrel than with clopidogrel but with more bleeding. We compared prasugrel with clopidogrel among subjects with DM in TRITON-TIMI 38. METHODS AND RESULTS: We classified 13 608 subjects on the basis of preexisting history of DM and further according to insulin use.…
Citation impact
- FWCI
- 48.34
- Percentile
- 100%
- References
- 42
Authors
12- SDStephen D. WiviottCorresponding
St. Michael's Hospital, Radboud University Nijmegen, Pontificia Universidad Católica de Chile, Milpark Hospital, Blackstone (United States), Hillel Yaffe Medical Center, University of Florida, Black Hills State University, Florida College
- EBEugene Braunwald
St. Michael's Hospital, Radboud University Nijmegen, Pontificia Universidad Católica de Chile, Milpark Hospital, Blackstone (United States), Hillel Yaffe Medical Center, University of Florida, Black Hills State University, Florida College
- DJDominick J. Angiolillo
St. Michael's Hospital, Radboud University Nijmegen, Pontificia Universidad Católica de Chile, Milpark Hospital, Blackstone (United States), Hillel Yaffe Medical Center, University of Florida, Black Hills State University, Florida College
- SMSimcha Meisel
St. Michael's Hospital, Radboud University Nijmegen, Pontificia Universidad Católica de Chile, Milpark Hospital, Blackstone (United States), Hillel Yaffe Medical Center, University of Florida, Black Hills State University, Florida College
- AJAnthony J. Dalby
St. Michael's Hospital, Radboud University Nijmegen, Pontificia Universidad Católica de Chile, Milpark Hospital, Blackstone (United States), Hillel Yaffe Medical Center, University of Florida, Black Hills State University, Florida College
Topics & keywords
- Prasugrel
- Medicine
- Clopidogrel
- Internal medicine
- TIMI
- Myocardial infarction
- Cardiology
- Diabetes mellitus
- Good health and well-being