Loss of stearoyl–CoA desaturase-1 function protects mice against adiposity
Howard Hughes Medical Institute · University of Wisconsin–Madison · +1 more institution
Abstract
Stearoyl-CoA desaturase (SCD) is a central lipogenic enzyme catalyzing the synthesis of monounsaturated fatty acids, mainly oleate (C18:1) and palmitoleate (C16:1), which are components of membrane phospholipids, triglycerides, wax esters, and cholesterol esters. Several SCD isoforms (SCD1-3) exist in the mouse. Here we show that mice with a targeted disruption of the SCD1 isoform have reduced body adiposity, increased insulin sensitivity, and are resistant to diet-induced weight gain. The protection from obesity involves increased energy expenditure and increased oxygen consumption. Compared with the wild-type mice the SCD1-/- mice have increased levels of plasma ketone bodies but reduced levels of plasma…
Citation impact
- FWCI
- 15.09
- Percentile
- 100%
- References
- 38
Authors
10- JMJames M. NtambiCorresponding
Howard Hughes Medical Institute, University of Wisconsin–Madison, Rockefeller University
- MMMakoto Miyazaki
Howard Hughes Medical Institute, University of Wisconsin–Madison, Rockefeller University
- JPJonathan P. Stoehr
Howard Hughes Medical Institute, University of Wisconsin–Madison, Rockefeller University
- LHLan Hong
Howard Hughes Medical Institute, University of Wisconsin–Madison, Rockefeller University
- CKChristina Kendziorski
Howard Hughes Medical Institute, University of Wisconsin–Madison, Rockefeller University
Topics & keywords
- Stearoyl-CoA Desaturase
- Internal medicine
- Endocrinology
- Chemistry
- Enzyme
- Triglyceride
- Gene isoform
- Lipid metabolism
- Affordable and clean energy