Cardiovascular Risk Factors Emerge After Artificial Selection for Low Aerobic Capacity
University of Toledo Medical Center · Norwegian University of Science and Technology · +4 more institutions
Abstract
In humans, the strong statistical association between fitness and survival suggests a link between impaired oxygen metabolism and disease. We hypothesized that artificial selection of rats based on low and high intrinsic exercise capacity would yield models that also contrast for disease risk. After 11 generations, rats with low aerobic capacity scored high on cardiovascular risk factors that constitute the metabolic syndrome. The decrease in aerobic capacity was associated with decreases in the amounts of transcription factors required for mitochondrial biogenesis and in the amounts of oxidative enzymes in skeletal muscle. Impairment of mitochondrial function may link reduced fitness to cardiovascular and…
Citation impact
- FWCI
- 25.44
- Percentile
- 100%
- References
- 17
Authors
11- UWUlrik WisløffCorresponding
University of Toledo Medical Center, Norwegian University of Science and Technology, Williams College, University of Michigan, St Olav's University Hospital, Michigan Medicine
- SMSonia M. NajjarCorresponding
University of Toledo Medical Center, Norwegian University of Science and Technology, Williams College, University of Michigan, St Olav's University Hospital, Michigan Medicine
- ØEØyvind Ellingsen
University of Toledo Medical Center, Norwegian University of Science and Technology, Williams College, University of Michigan, St Olav's University Hospital, Michigan Medicine
- PMPer Magnus Haram
University of Toledo Medical Center, Norwegian University of Science and Technology, Williams College, University of Michigan, St Olav's University Hospital, Michigan Medicine
- SJSteven J. Swoap
University of Toledo Medical Center, Norwegian University of Science and Technology, Williams College, University of Michigan, St Olav's University Hospital, Michigan Medicine
Topics & keywords
- Mitochondrial biogenesis
- Aerobic capacity
- Disease
- Aerobic exercise
- VO2 max
- Biogenesis
- Metabolic syndrome
- Biology
- Good health and well-being