Identification and Characterization of Ovarian Cancer-Initiating Cells from Primary Human Tumors
Shanghai Jiao Tong University · Renji Hospital · +9 more institutions
Abstract
The objective of this study was to identify and characterize a self-renewing subpopulation of human ovarian tumor cells (ovarian cancer-initiating cells, OCICs) fully capable of serial propagation of their original tumor phenotype in animals. Ovarian serous adenocarcinomas were disaggregated and subjected to growth conditions selective for self-renewing, nonadherent spheroids previously shown to derive from tissue stem cells. To affirm the existence of OCICs, xenoengraftment of as few as 100 dissociated spheroid cells allowed full recapitulation of the original tumor (grade 2/grade 3 serous adenocarcinoma), whereas >10(5) unselected cells remained nontumorigenic. Stemness properties of OCICs (under stem…
Citation impact
- FWCI
- 34.39
- Percentile
- 100%
- References
- 60
Authors
9- SZShu ZhangCorresponding
Shanghai Jiao Tong University, Renji Hospital, Indiana University Bloomington, Indiana University School of Medicine
- CBCurt Balch
Indiana University Bloomington, Indiana University School of Medicine, Indiana University
- MWMichael W.Y. Chan
National Chung Cheng University
- HLHung‐Cheng Lai
Tri-Service General Hospital, National Defense Medical Center
- DMDaniela Matei
Immunovaccine (Canada), Indiana University School of Medicine, Indiana University – Purdue University Indianapolis, Indiana University
Topics & keywords
- CD117
- Cancer stem cell
- CD44
- Ovarian cancer
- Homeobox protein NANOG
- Biology
- Cancer research
- Stem cell
- Good health and well-being