Interactions between gut microbiota, host genetics and diet relevant to development of metabolic syndromes in mice

Both genetic variations and diet-disrupted gut microbiota can predispose animals to metabolic syndromes (MS). This study assessed the relative contributions of host genetics and diet in shaping the gut microbiota and modulating MS-relevant phenotypes in mice. Together with its wild-type (Wt) counterpart, the Apoa-I knockout mouse, which has impaired glucose tolerance (IGT) and increased body fat, was fed a high-fat diet (HFD) or normal chow (NC) diet for 25 weeks. DNA fingerprinting and bar-coded pyrosequencing of 16S rRNA genes were used to profile gut microbiota structures and to identify the key population changes relevant to MS development by Partial Least Square Discriminate Analysis. Diet changes…

• NN
  National Natural Science Foundation of China

  Awards: 30821005, 863 Program, 2008AA02Z315
• CA
  Chinese Academy of Sciences

  Award: KSCX1-YW-02
• NH
  National High-tech Research and Development Program
• NK
  National Key Research and Development Program of China